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Dysregulation of different classes of tRNA fragments in chronic lymphocytic leukemia

13 Nov 2019

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is the most common human leukemia, and dysregulation of tRNA-derived short noncoding RNA (tsRNA) (tRF-1) expression is an accompanying event in the development of this disease. tsRNAs are fragments originating from the 3′ end of tRNA precursors and do not contain mature tRNA sequences. In contrast to tsRNAs, mature tRFs (tRF-3s, tRF-5s, and internal tRFs) are produced from...

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PMID: 31723042
DOI: 10.1073/pnas.1913695116

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