Article
Dysregulation of a family of short noncoding RNAs, tsRNAs, in human cancer.
Proceedings of the National Academy of Sciences of the United States of America - 3 May 2016
Pekarsky Yuri, Balatti Veronica, Palamarchuk Alexey, Rizzotto Lara, Veneziano Dario, Nigita Giovanni, Rassenti Laura Z, Pass Harvey I, Kipps Thomas J, Liu Chang-Gong, Croce Carlo M
Abstract excerpt
Chronic lymphocytic leukemia (CLL) is the most common human leukemia, and transgenic mouse studies indicate that activation of the T-cell leukemia/lymphoma 1 (TCL1) oncogene is a contributing event in the pathogenesis of the aggressive form of this disease. While studying the regulation of TCL1 expression, we identified the microRNA cluster miR-4521/3676 and discovered that these two microRNAs are associated with...
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