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LANA and hnRNP A1 Regulate the Translation of LANA mRNA through G-Quadruplexes

11 Nov 2019

Abstract excerpt

LANA, the most abundantly expressed protein during latency, is a multifunctional protein which is absolutely required for the persistence of KSHV in the host cell. Even though the functions of LANA in aiding pathogenesis of the virus have been extensively studied, the mechanism of how LANA escapes host's immune surveillance is not fully understood. This study sheds light on the autoregulatory role of LANA to...

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PMID: 31723020
DOI: 10.1128/jvi.01508-19

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