Article
Persistence of Inflammatory Phenotype in Residual Psoriatic Plaques in Patients on Effective Biologic Therapy.
The Journal of investigative dermatology - 1 May 2020
Mashiko Shunya, Edelmayer Rebecca M, Bi Yingtao, Olson Lauren M, Wetter Joseph B, Wang Jing, Maari Catherine, Saint-Cyr Proulx Etienne, Kaimal Vivek, Li Xuan, Salte Katherine, Garcet Sandra, Kannan Arun K, Huang Susan M, Cao Xiaohong, Liu Zheng, Krueger James G, Sarfati Marika, Bissonnette Robert, Smith Kathleen M
Abstract excerpt
Many psoriasis patients treated with biologics do not achieve total skin clearance. These patients possess residual plaques despite ongoing biologic treatment. To elucidate mechanisms of plaque persistence despite overall good drug response, we studied 50 subjects: psoriasis patients with residual plaques treated with one of three different biologics, untreated patients, and healthy controls. Skin biopsies from...
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