Article
Intraepidermal lymphocytes in psoriatic lesions are activated GMP-17(TIA-1)+CD8+CD3+ CTLs as determined by phenotypic analysis.
Journal of cutaneous pathology - 1 Feb 1998
Austin L M, Coven T R, Bhardwaj N, Steinman R, Krueger J G
Abstract excerpt
The onset and persistence of psoriatic lesions are linked to the presence of an inflammatory infiltrate of CD3+ lymphocytes that includes CD4+ and CD8+ subsets. Since a primary susceptibility factor for psoriasis is the Class I HLA-Cw6 molecule, we set out to learn more about the features of the...
Topics
- CD3 Complex
- CD8 Antigens
- Epidermis
- Flow Cytometry
- Granulocyte Colony-Stimulating Factor
- Humans
- Immunohistochemistry
- Lymphocyte Activation
- Lymphocytes
- Membrane Proteins
- Phenotype
- Poly(A)-Binding Proteins
- Proteins
- Psoriasis
- RNA-Binding Proteins
- Skin
- T-Cell Intracellular Antigen-1
- T-Lymphocyte Subsets