Article
Genome sequencing of evolved aspergilli populations reveals robust genomes, transversions in A. flavus, and sexual aberrancy in non-homologous end-joining mutants.
BMC biology - 11 Nov 2019
Álvarez-Escribano Isidro, Sasse Christoph, Bok Jin Woo, Na Hyunsoo, Amirebrahimi Mojgan, Lipzen Anna, Schackwitz Wendy, Martin Joel, Barry Kerrie, Gutiérrez Gabriel, Cea-Sánchez Sara, Marcos Ana T, Grigoriev Igor V, Keller Nancy P, Braus Gerhard H, Cánovas David
Abstract excerpt
BACKGROUND: Aspergillus spp. comprises a very diverse group of lower eukaryotes with a high relevance for industrial applications and clinical implications. These multinucleate species are often cultured for many generations in the laboratory, which can unknowingly propagate hidden genetic mutations. To assess the likelihood of such events, we studied the genome stability of aspergilli by using a combination of...
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