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Article

The circadian clock is associated with prognosis and immune infiltration in stomach adenocarcinoma.

Aging - 23 Jun 2021

Huang Zhihao, He Aoxiao, Wang Jiakun, Lu Hongcheng, Zhang Rongguiyi, Wu Linquan, Feng Qian

Abstract excerpt

BACKGROUND: Stomach adenocarcinoma (STAD) is one of the most prevalent malignances and ranks fifth in incidence and third in cancer-related death among all malignances. The prognosis of STAD is poor. The circadian clock is regulated by interlocked transcriptional-translational feedback loops that orchestrate circadian rhythms in some biological processes, including the immune response and metabolism. However, the...

Topics

Adenocarcinoma
Antineoplastic Agents
CLOCK Proteins
Circadian Clocks
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Lymphocytes, Tumor-Infiltrating
Mutation
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reproducibility of Results

Stomach Neoplasms

Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 34162762
DOI: 10.18632/aging.203184
PMCID: PMC8266362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-34162762-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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