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Single-cell RNA sequencing integrated with bulk RNA sequencing analysis of clock circadian regulator with prognostic and immune microenvironment in thyroid cancer

31 Jan 2025

Abstract excerpt

• CLOCK protein is overexpressed in thyroid cancer compared to normal tissue in both mouse models and human samples. • A prognostic model incorporating CLOCK and related genes was developed using LASSO regression. • CLOCK knockdown hinders tumor growth and the activity of MAPK signaling in thyroid cancer. • CLOCK may inhibit immune infiltration within the tumor microenvironment. • High CLOCK expression is linked...

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PMID: 39892222
DOI: 10.1016/j.tranon.2025.102299

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