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Article

Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer

7 Nov 2019

Abstract excerpt

According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in several cancers. However, the exact mechanism of CBD action is not currently understood. Here, CBD promoted cell death in gastric cancer. We suggest that CBD induced apoptosis by suppressing X-linked inhibitor apoptosis (XIAP), a member of the IAP protein family. CBD reduced XIAP protein levels...

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PMID: 31699976
DOI: 10.1038/s41419-019-2001-7

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