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Article

Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population

7 Nov 2019

Abstract excerpt

OBJECTIVE: The causality and pathogenic mechanism of microbiome composition remain elusive in many diseases, including autoimmune diseases such as rheumatoid arthritis (RA). This study aimed to elucidate gut microbiome's role in RA pathology by a comprehensive metagenome-wide association study (MWAS). METHODS: =42) by using whole-genome shotgun sequencing of high depth (average 13 Gb per sample). Our MWAS...

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PMID: 31699813
DOI: 10.1136/annrheumdis-2019-215743

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