Article
Tumor antigens heterogeneity and immune response-targeting neoantigens in breast cancer.
Seminars in cancer biology - 1 Jul 2021
Benvenuto Monica, Focaccetti Chiara, Izzi Valerio, Masuelli Laura, Modesti Andrea, Bei Roberto
Abstract excerpt
Breast cancer is both the most common type of cancer and the most frequent cause of cancer mortality in women, mainly because of its heterogeneity and limited immunogenicity. The aim of specific active cancer immunotherapy is to stimulate the host's immune response against cancer cells directly using a vaccine platform carrying one or more tumor antigens. In particular, the ideal tumor antigen should be able to...
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