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Article

Cre-inducible Adeno Associated Virus-mediated Expression of P301L Mutant Tau Causes Motor Deficits and Neuronal Degeneration in the Substantia Nigra.

Neuroscience - 1 Dec 2019

You Yang, Botros Mina B, Enoo Alicia A Van, Bockmiller Aaron, Herron Shawn, Delpech Jean Christophe, Ikezu Tsuneya

Abstract excerpt

Accumulation of microtubule associated protein tau in the substantia nigra is associated with several tauopathies including progressive supranuclear palsy (PSP). A number of studies have used mutant tau transgenic mouse model to mimic the neuropathology of tauopathies and disease phenotypes. However, tau expression in these transgenic mouse models is not specific to brain subregions, and may not recapitulate...

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Identifiers

PMID: 31689387
DOI: 10.1016/j.neuroscience.2019.10.001
PMCID: PMC6898791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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