Article
In vitro fertilization does not increase the incidence of de novo copy number alterations in fetal and placental lineages.
Nature medicine - 1 Nov 2019
Zamani Esteki Masoud, Viltrop Triin, Tšuiko Olga, Tiirats Airi, Koel Mariann, Nõukas Margit, Žilina Olga, Teearu Katre, Marjonen Heidi, Kahila Hanna, Meekels Jeroen, Söderström-Anttila Viveca, Suikkari Anne-Maria, Tiitinen Aila, Mägi Reedik, Kõks Sulev, Kaminen-Ahola Nina, Kurg Ants, Voet Thierry, Vermeesch Joris Robert, Salumets Andres
Abstract excerpt
Although chromosomal instability (CIN) is a common phenomenon in cleavage-stage embryogenesis following in vitro fertilization (IVF)1-3, its rate in naturally conceived human embryos is unknown. CIN leads to mosaic embryos that contain a combination of genetically normal and abnormal cells, and is significantly higher in in vitro-produced preimplantation embryos as compared to in vivo-conceived preimplantation...
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