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Article

Staphylococcus aureus small colony variants impair host immunity by activating host cell glycolysis and inducing necroptosis.

Nature microbiology - 1 Jan 2020

Wong Fok Lung Tania, Monk Ian R, Acker Karen P, Mu Andre, Wang Nancy, Riquelme Sebastián A, Pires Silvia, Noguera Loreani P, Dach Felix, Gabryszewski Stanislaw J, Howden Benjamin P, Prince Alice

Abstract excerpt

Staphylococcus aureus small colony variants (SCVs) are frequently associated with chronic infection, yet they lack expression of many virulence determinants associated with the pathogenicity of wild-type strains. We found that both wild-type S. aureus and a ΔhemB SCV prototype potently activate glycolysis in host cells. Glycolysis and the generation of mitochondrial reactive oxygen species were sufficient to...

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Identifiers

PMID: 31686028
DOI: 10.1038/s41564-019-0597-0
PMCID: PMC10184863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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