Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A New Strategy for Identifying Mechanisms of Drug-drug Interaction Using Transcriptome Analysis: Compound Kushen Injection as a Proof of Principle.

Scientific reports - 4 Nov 2019

Shen Hanyuan, Qu Zhipeng, Harata-Lee Yuka, Cui Jian, Aung Thazin Nwe, Wang Wei, Kortschak R Daniel, Adelson David L

Abstract excerpt

Drug-drug interactions (DDIs), especially with herbal medicines, are complex, making it difficult to identify potential molecular mechanisms and targets. We introduce a workflow to carry out DDI research using transcriptome analysis and interactions of a complex herbal mixture, Compound Kushen Injection (CKI), with cancer chemotherapy drugs, as a proof of principle. Using CKI combined with doxorubicin or 5-Fu on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Checkpoints
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Doxorubicin

Share to Drug Interactions

Share to Drugs, Chinese Herbal

Share to Fluorouracil

Share to Myeloid Differentiation Factor 88

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 31685921
DOI: 10.1038/s41598-019-52375-3
PMCID: PMC6828681

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A New Strategy for Identifying Mechanisms of Drug-drug Interaction Using Transcriptome Analysis: Compound Kushen Injection as a Proof of Principle.PMID 31685921Read ↗

The Effect of Compound Kushen Injection on Cancer Cells: Integrated Identification of Candidate Molecular MechanismsSemantic proximity Read ↗

The effect of compound kushen injection on cancer cells: Integrated identification of candidate molecular mechanismsSemantic proximity Read ↗

Validating the Target Functions and Synergistic Multi-Target, Multi-Pathway Action Mode of Compound Kushen Injection Using CRISPR/CASSemantic proximity Read ↗

Network Pharmacology-Based Study on the Molecular Biological Mechanism of Action for Compound Kushen Injection in Anti-Cancer EffectSemantic proximity Read ↗

Molecular mechanisms of phytochemicals from <i>Zanthoxylum nitidum</i> (Roxb.) DC. against hepatocellular carcinoma: insights from network pharmacology, molecular docking, and bioinformaticsSemantic proximity Read ↗

A metabolic data-driven systems pharmacology strategy for decoding and validating the mechanism of Compound Kushen Injection against HCC.Semantic proximity Read ↗

Predicting protein targets for drug-like compounds using transcriptomicsSemantic proximity Read ↗

A systems pharmacology approach to determine the mechanisms of action of pleiotropic natural products in breast cancer from transcriptome dataSemantic proximity Read ↗

Identification of Gedunin from a Phytochemical Depository as a Novel Multidrug Resistance-Bypassing Tubulin Inhibitor of Cancer CellsSemantic proximity Read ↗

Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer TherapySemantic proximity Read ↗

Elucidating the modes of action for bioactive compounds in a cell-specific manner by large-scale chemically-induced transcriptomicsSemantic proximity Read ↗

The gene expression profiles in response to 102 traditional Chinese medicine (TCM) components: a general template for research on TCMsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.