Article
Effects of indirect actions and oxygen on relative biological effectiveness: estimate of DSB inductions and conversions induced by therapeutic proton beams.
International journal of radiation biology - 1 Feb 2020
Luo Wei-Ren, Chen Fang-Hsin, Huang Ren-Jing, Chen Yu-Pin, Hsiao Ya-Yun
Abstract excerpt
Purpose: This study evaluated the DNA double strand breaks (DSBs) induced by indirect actions and its misrepairs to estimate the relative biological effectiveness (RBE) of proton beams.Materials and methods: From experimental data, DSB induction was evaluated in cells irradiated by 62 MeV proton beams in the presence of dimethylsulphoxide (DMSO) and under hypoxic conditions. The DNA damage yields for calculating...
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