Article
Clinical implications of GWAS variants associated with differentiated thyroid cancer.
Endokrynologia Polska - 1 Jan 2019
Jendrzejewski Jarosław P, Sworczak Krzysztof, Comiskey Daniel F, de la Chapelle Albert
Abstract excerpt
The genetic risk of differentiated thyroid cancer (DTC) probably consists of multiple low-penetrance, single-nucleotide polymorphisms (SNP). Such markers are difficult to uncover by linkage analysis but can be revealed by association studies. Genome-wide association studies (GWASs) have uncovered 31 SNPs associated with DTC. These markers carry a low to moderate risk for DTC, but their cumulative effect increases...
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