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Article

Biological depletion of neutrophils attenuates pro-inflammatory markers and the development of the psoriatic phenotype in a murine model of psoriasis.

Clinical immunology (Orlando, Fla.) - 1 Jan 2020

Han George, Havnaer Annika, Lee Hiu Ham, Carmichael Dylan J, Martinez Luis R

Abstract excerpt

Although neutrophils are considered a histologic hallmark of psoriasis, their pathophysiologic role in psoriasis remains unclear. We characterized the effects of neutrophil depletion via injection of monoclonal antibody 1A8 on the development of imiquimod (IMQ)-induced psoriatic lesions in a murine model. Lesions were followed with photographs and histologic analysis, revealing reduced psoriasiform scale and...

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Identifiers

PMID: 31678366
DOI: 10.1016/j.clim.2019.108294
PMCID: PMC8043213

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