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Zika NS2B is a crucial factor recruiting NS3 to the ER and activating its protease activity.

Virus research - 2 Jan 2020

Xing Huaipeng, Xu Shan, Jia Fangfei, Yang Yang, Xu Caimin, Qin Chengfeng, Shi Lei

Abstract excerpt

Zika virus (ZIKV) is an emergent flavivirus associated with severe neurological disorders. ZIKV NS3 protein is a viral protease that cleaves the ZIKV polyprotein precursor into individual viral proteins. In this study, we found that ZIKV NS3 by itself exhibited mitochondrial localization, which was quite different from its endoplasmic reticulum (ER) localization in ZIKV-infected cells. We screened viral proteins...

Topics

Endoplasmic Reticulum
HEK293 Cells
HeLa Cells
Humans
Mitochondria
Mutation
Peptide Hydrolases
Protein Binding
Serine Endopeptidases
Viral Nonstructural Proteins
Viral Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Replication

Zika Virus

Source

Identifiers

PMID: 31676367
DOI: 10.1016/j.virusres.2019.197793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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