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Comprehensive analysis of POLE and POLD1 Gene Variations identifies cancer patients potentially benefit from immunotherapy in Chinese population.

Scientific reports - 31 Oct 2019

Yao Jianfei, Gong Yuan, Zhao Wei, Han Zhifeng, Guo Shaohua, Liu Hongyi, Peng Xiumei, Xiao Wenhua, Li Yuemin, Dang Shiying, Liu Guifeng, Li Lifeng, Huang Tanxiao, Chen Shifu, Song Lele

Abstract excerpt

POLE/POLD1 gene variants have been suggested as potential markers for immunotherapy due to their significant association with the tumor mutational burden (TMB), an effective indicator for response prediction in immunotherapy. However, the correlation of POLE/POLD1 variants with MSI, MMR, TMB, MMR-related and key driver gene mutations needs to be defined to support patient recruitment and therapeutic effect...

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Identifiers

PMID: 31673068
DOI: 10.1038/s41598-019-52414-z
PMCID: PMC6823448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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