Article
Oncobox Method for Scoring Efficiencies of Anticancer Drugs Based on Gene Expression Data.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020
Tkachev Victor, Sorokin Maxim, Garazha Andrew, Borisov Nicolas, Buzdin Anton
Abstract excerpt
We describe here the Oncobox method for scoring efficiencies of anticancer target drugs (ATDs) using high throughput gene expression data. The method rationale, design, and validation are given along with the examples of its practical applications in biomedicine. The method is based on the analysis of intracellular molecular pathways activation and measuring expressions of molecular target genes for every ATD...
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