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Article

Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes

4 May 2004

Abstract excerpt

We developed concise, accurate prediction models of the in vitro activity for 8 anticancer drugs (5-FU, CDDP, MMC, DOX, CPT-11, SN-38, TXL and TXT), along with individual clinical responses to 5-FU using expression data of 12 genes. We first performed cDNA microarray analysis and MTT assay of 19 human cancer cell lines to sort out genes which were correlative in expression levels with cytotoxicities of the 8...

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PMID: 15239142
DOI: 10.1002/ijc.20289

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