Article
Common and Rare Sequence Variants Influencing Tumor Biomarkers in Blood.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2020
Olafsson Sigurgeir, Alexandersson Kristjan F, Gizurarson Johann G K, Hauksdottir Katrin, Gunnarsson Orvar, Olafsson Karl, Gudmundsson Julius, Stacey Simon N, Sveinbjornsson Gardar, Saemundsdottir Jona, Bjornsson Einar S, Olafsson Sigurdur, Bjornsson Sigurdur, Orvar Kjartan B, Vikingsson Arnor, Geirsson Arni J, Arinbjarnarson Sturla, Bjornsdottir Gyda, Thorgeirsson Thorgeir E, Sigurdsson Snaevar, Halldorsson Gisli H, Magnusson Olafur T, Masson Gisli, Holm Hilma, Jonsdottir Ingileif, Sigurdardottir Olof, Eyjolfsson Gudmundur I, Olafsson Isleifur, Sulem Patrick, Thorsteinsdottir Unnur, Jonsson Thorvaldur, Rafnar Thorunn, Gudbjartsson Daniel F, Stefansson Kari
Abstract excerpt
BACKGROUND: Alpha-fetoprotein (AFP), cancer antigens 15.3, 19.9, and 125, carcinoembryonic antigen, and alkaline phosphatase (ALP) are widely measured in attempts to detect cancer and to monitor treatment response. However, due to lack of sensitivity and specificity, their utility is debated. The serum levels of these markers are affected by a number of nonmalignant factors, including genotype. Thus, it may be...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Child