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Article

Genetic correlations between pain phenotypes and depression and neuroticism.

European journal of human genetics : EJHG - 1 Mar 2020

Meng Weihua, Adams Mark J, Reel Parminder, Rajendrakumar Aravind, Huang Yu, Deary Ian J, Palmer Colin N A, McIntosh Andrew M, Smith Blair H

Abstract excerpt

Correlations between pain phenotypes and psychiatric traits such as depression and the personality trait of neuroticism are not fully understood. In this study, we estimated the genetic correlations of eight pain phenotypes (defined by the UK Biobank, n = 151,922-226,683) with depressive symptoms, major depressive disorders and neuroticism using the the cross-trait linkage disequilibrium score regression (LDSC)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31659249
DOI: 10.1038/s41431-019-0530-2
PMCID: PMC7028719

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