Virtual internal exposures of lansoprazole administered to cytochrome P450 2C19 poor metabolizers estimated by simplified physiologically based pharmacokinetic modeling.

Abstract excerpt

Although the importance of polymorphic cytochrome P450 2C19 (CYP2C19) in the metabolism of proton pump inhibitors is well recognized, genotyping patients for CYP2C19 before prescribing proton pump inhibitors is not currently recommended in some Asian countries. Adverse events in patients prescribed 30-mg lansoprazole alone have been reported in the Japanese Adverse Drug Event Report database. This study aimed to...

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