Article
Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group.
Clinical and translational science - 1 Jan 2020
Caudle Kelly E, Sangkuhl Katrin, Whirl-Carrillo Michelle, Swen Jesse J, Haidar Cyrine E, Klein Teri E, Gammal Roseann S, Relling Mary V, Scott Stuart A, Hertz Daniel L, Guchelaar Henk-Jan, Gaedigk Andrea
Abstract excerpt
Translating CYP2D6 genotype to metabolizer phenotype is not standardized across clinical laboratories offering pharmacogenetic (PGx) testing and PGx clinical practice guidelines, such as the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Dutch Pharmacogenetics Working Group (DPWG). The genotype to phenotype translation discordance between laboratories and guidelines can cause discordant...
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