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Generation of three iPSC lines from fibroblasts of a patient with Aicardi Goutières Syndrome mutated in TREX1.

Stem cell research - 1 Dec 2019

Ferraro Rosalba Monica, Lanzi Gaetana, Masneri Stefania, Barisani Chiara, Piovani Giovanna, Savio Giulia, Cattalini Marco, Galli Jessica, Cereda Cristina, Muzi-Falconi Marco, Orcesi Simona, Fazzi Elisa, Giliani Silvia

Abstract excerpt

Fibroblasts from a patient with Aicardi Goutières Syndrome (AGS) carrying a compound heterozygous mutation in TREX1, were reprogrammed into induced pluripotent stem cells (iPSCs) to establish isogenic clonal stem cell lines: UNIBSi006-A, UNIBSi006-B, and UNIBSi006-C. Cells were transduced using the episomal Sendai viral vectors, containing human OCT4, SOX2, c-MYC and KLF4 transcription factors. The transgene-free...

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PMID: 31644995
DOI: 10.1016/j.scr.2019.101580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Generation of three iPSC lines from fibroblasts of a patient with Aicardi Goutières Syndrome mutated in TREX1.PMID 31644995Read ↗

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