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Establishment of three iPSC lines from fibroblasts of a patient with Aicardi Goutières syndrome mutated in RNaseH2B.

Stem cell research - 1 Dec 2019

Ferraro Rosalba Monica, Masneri Stefania, Lanzi Gaetana, Barisani Chiara, Piovani Giovanna, Savio Giulia, Cattalini Marco, Galli Jessica, Cereda Cristina, Muzi-Falconi Marco, Orcesi Simona, Fazzi Elisa, Giliani Silvia

Abstract excerpt

We report the generation of three isogenic iPSC clones (UNIBSi007-A, UNIBSi007-B, and UNIBSi007-C) obtained from fibroblasts of a patient with Aicardi Goutières Syndrome (AGS) carrying a homozygous mutation in RNaseH2B. Cells were transduced using a Sendai virus based system, delivering the human OCT4, SOX2, c-MYC and KLF4 transcription factors. The resulting transgene-free iPSC lines retained the disease-causing...

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PMID: 31678772
DOI: 10.1016/j.scr.2019.101620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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