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Article

A novel BMI-1 inhibitor QW24 for the treatment of stem-like colorectal cancer

22 Oct 2019

Abstract excerpt

BACKGROUND: Cancer-initiating cell (CIC), a functionally homogeneous stem-like cell population, is resonsible for driving the tumor maintenance and metastasis, and is a source of chemotherapy and radiation-therapy resistance within tumors. Targeting CICs self-renewal has been proposed as a therapeutic goal and an effective approach to control tumor growth. BMI-1, a critical regulator of self-renewal in the...

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PMID: 31640758
DOI: 10.1186/s13046-019-1392-8

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