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Alteration in TET1 as potential biomarker for immune checkpoint blockade in multiple cancers

17 Oct 2019

Abstract excerpt

BACKGROUND: Immune checkpoint inhibitors (ICIs) have achieved impressive success in different cancer types, yet responses vary and predictive biomarkers are urgently needed. Growing evidence points to a link between DNA methylation and anti-tumor immunity, while clinical data on the association of genomic alterations in DNA methylation-related genes and ICI response are lacking. METHODS: Clinical cohorts with...

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PMID: 31623662
DOI: 10.1186/s40425-019-0737-3

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