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Article

Atherosclerosis: integration of its pathogenesis as a self-perpetuating propagating inflammation: a review

1 Jun 2019

Abstract excerpt

This review proposes that the development of the atherosclerotic plaque is critically dependent on its inflammatory components forming a self-perpetuating and propagating positive feedback loop. The components involved are: (1) LDL oxidation, (2) activation of the endothelium, (3) recruitment of inflammatory monocytes, (4) macrophage accumulation, which induces LDL oxidation, and (5) macrophage generation of...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 31588428
DOI: 10.1097/xce.0000000000000172

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