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Salmonella effector SpvB interferes with intracellular iron homeostasis via regulation of transcription factor NRF2

30 Sept 2019

Abstract excerpt

Iron is a necessary nutrient for humans and nearly all bacterial species. During Salmonella infection, macrophages limit the availability of iron to intracellular pathogens in one of the central components of nutritional immunity. However, Salmonella also have mechanisms to interfere with the antimicrobial effect of host iron withdrawal and meet their own nutrient requirements by scavenging iron from the host....

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PMID: 31569998
DOI: 10.1096/fj.201900883rr

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