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Article

Resolving a clinical tuberculosis outbreak using palaeogenomic genome reconstruction methodologies.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2019

Jones Rhys, Velasco Marcela Sandoval, Harris Llinos G, Morgan Sue, Temple Mark, Ruddy Michael C, Williams Rhian, Perry Michael D, Hitchings Matt, Wilkinson Thomas S, Humphrey Thomas, Gilbert M Thomas P, Davies Angharad P

Abstract excerpt

This study describes the analysis of DNA from heat-killed (boilate) isolates of Mycobacterium tuberculosis from two UK outbreaks where DNA was of sub-optimal quality for the standard methodologies routinely used in microbial genomics. An Illumina library construction method developed for sequencing ancient DNA was successfully used to obtain whole genome sequences, allowing analysis of the outbreak by...

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Identifiers

PMID: 31563810
DOI: 10.1016/j.tube.2019.101865

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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