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Article

GRWD1 directly interacts with p53 and negatively regulates p53 transcriptional activity

18 Sept 2019

Abstract excerpt

Glutamate-rich WD40 repeat containing 1 (GRWD1) functions as a histone chaperone to promote loading of the MCM replication helicase at replication origins. GRWD1 is overexpressed in several cancer cell lines, and GRWD1 overexpression confers tumorigenic potential in human cells. However, less is known concerning its oncogenic activity. Our previous analysis showed that GRWD1 negatively regulates the tumour...

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PMID: 31545368
DOI: 10.1093/jb/mvz075

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