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Article

Clinical significance and biological function of WD repeat domain 54 as an oncogene in colorectal cancer

10 Jul 2018

Abstract excerpt

In recent years, protein-protein interactions have become an attractive candidate for identifying biomarkers and drug targets for various diseases. However, WD40 repeat (WDR) domain proteins, some of the most abundant mediators of protein interactions, are largely unexplored. In our study, 57 of 361 known WDR proteins were identified as hub nodes, and a hub (WDR54) with elevated mRNA in colorectal cancer (CRC)...

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PMID: 29987896
DOI: 10.1002/ijc.31736

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