Reduced matrix metalloproteinase and collagen transcription mediated by the TGF‐β/Smad pathway in passaged normal human dermal fibroblasts

Abstract excerpt

BACKGROUND: Transforming growth factor-β (TGF-β) is a major regulator of extracellular matrix (ECM) events, particularly collagen production. AIM: We explored whether the expression of matrix metalloproteinases (MMPs) and collagen are transcriptionally regulated by the TGF-β and Smad signaling pathways, and the roles played by NF-κB and mitogen-activated protein kinase (MAPK) signaling in normal, aged, human...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Skin Protection and Aging
• Share to TGF-β signaling in diseases
• Share to Wound Healing and Treatments