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Article

Molecular determinants of response to high-dose androgen therapy in prostate cancer

11 Sept 2019

Abstract excerpt

Clinical trials of high-dose androgen (HDA) therapy for prostate cancer (PC) have shown promising efficacy but are limited by lack of criteria to identify likely responders. To elucidate factors that govern the growth-repressive effects of HDAs, we applied an unbiased integrative approach using genetic screens and transcriptional profiling of PC cells with or without demonstrated phenotypic sensitivity to...

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Share to Hormonal and reproductive studies
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PMID: 31503550
DOI: 10.1172/jci.insight.129715

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