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Article

Exploring the cancer stem cell phenotype with high-throughput screening applications.

Future medicinal chemistry - 1 Jun 2012

Wurdak Heiko

Abstract excerpt

Several human cancer types consist of diverse cell populations that can differ in their tumor-driving potential. One breakthrough has been the identification of poorly differentiated tumor cells, herein termed cancer stem cells (CSCs). CSCs have been shown to initiate tumors in different model systems and have been implicated in cancer resistance to conventional therapies. The clinical relevance of CSCs has been...

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Identifiers

PMID: 22800368
DOI: 10.4155/fmc.12.73

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