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Identification of key genes controlling breast cancer stem cell characteristics via stemness indices analysis

12 Feb 2020

Abstract excerpt

BACKGROUND: With the gradual unveiling of tumour heterogeneity, cancer stem cells (CSCs) are now being considered the initial component of tumour initiation. However, the mechanisms of the growth and maintenance of breast cancer (BRCA) stem cells are still unknown. METHODS: To explore the crucial genes modulating BRCA stemness characteristics, we combined the gene expression value and mRNA expression-based...

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PMID: 32050983
DOI: 10.1186/s12967-020-02260-9

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