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Article

BK channels regulate extracellular Tat-mediated HIV-1 LTR transactivation

22 Aug 2019

Abstract excerpt

Abstract HIV-1 Tat is essential for HIV-1 replication and plays an important role in latent HIV-1 infection, HIV-1 associated neurological complication, and other HIV-1 comorbidities. Secreted from HIV-1 infected or transfected cells, Tat can be up-taken into cells by receptor-mediated endocytosis and internalized into endolysosomes. To reach nucleus where it can facilitate HIV-1 viral replication, exogenous Tat...

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PMID: 31439883
DOI: 10.1038/s41598-019-48777-y

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