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HIV‐1 Tat endocytosis and retention in endolysosomes affects HIV‐1 Tat‐induced LTR transactivation in astrocytes

3 Feb 2022

Abstract excerpt

The presence of latent HIV-1 reservoirs in the periphery and brain represents a major obstacle to curing HIV-1 infection. As an essential protein for HIV-1 viral replication, HIV-1 Tat, mostly intracellular, has been implicated in latent HIV-1 infection. From HIV-1 infected cells, HIV-1 Tat is actively secreted and bystander cells uptake the released Tat whereupon it is endocytosed and internalized into...

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PMID: 35113458
DOI: 10.1096/fj.202101722r

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