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Function of the CRISPR-Cas System of the Human Pathogen Clostridium difficile

2 Sept 2015

Abstract excerpt

UNLABELLED: Clostridium difficile is the cause of most frequently occurring nosocomial diarrhea worldwide. As an enteropathogen, C. difficile must be exposed to multiple exogenous genetic elements in bacteriophage-rich gut communities. CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) systems allow bacteria to adapt to foreign genetic invaders. Our recent data revealed...

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PMID: 26330515
DOI: 10.1128/mbio.01112-15

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