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Article

Metal-independent variants of phosphoglycerate mutase promote resistance to nutritional immunity and retention of glycolysis during infection.

PLoS pathogens - 1 Jul 2019

Radin Jana N, Kelliher Jessica L, Solórzano Paola K Párraga, Grim Kyle P, Ramezanifard Rouhallah, Slauch James M, Kehl-Fie Thomas E

Abstract excerpt

The ability of Staphylococcus aureus and other pathogens to consume glucose is critical during infection. However, glucose consumption increases the cellular demand for manganese sensitizing S. aureus to host-imposed manganese starvation. The current investigations were undertaken to elucidate how S. aureus copes with the need to consume glucose when metal-limited by the host. A critical component of host defense...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31344131
DOI: 10.1371/journal.ppat.1007971
PMCID: PMC6684088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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