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Article

Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2019

Takada Yoko K, Yu Jessica, Shimoda Michiko, Takada Yoshikazu

Abstract excerpt

CD40L plays a major role in immune response and is a major therapeutic target for inflammation. Integrin α5β1 and CD40 simultaneously bind to CD40L. It is unclear if α5β1 and CD40 work together in CD40/CD40L signaling or how α5β1 binds to CD40L. In this article, we describe that the integrin-binding site of human CD40L is predicted to be located in the trimeric interface by docking simulation. Mutations in the...

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Share to CD40 Antigens
Share to CD40 Ligand
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 31331973
DOI: 10.4049/jimmunol.1801630

Genes

CD40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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