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Article

High-intensity interval training modulates retinal microvascular phenotype and DNA methylation of p66Shc gene: a randomized controlled trial (EXAMIN AGE).

European heart journal - 14 Apr 2020

Streese Lukas, Khan Abdul Waheed, Deiseroth Arne, Hussain Shafaat, Suades Rosa, Tiaden Andre, Kyburz Diego, Cosentino Francesco, Hanssen Henner

Abstract excerpt

AIMS: Impairments of retinal vessel diameter are associated with major adverse cardiovascular (CV) events. Promoter DNA methylation is a repressor of the mitochondrial adaptor p66Shc gene transcription, a key driver of ageing-induced reactive oxygen species. The study aimed to investigate whether high-intensity interval training (HIIT) affects retinal microvascular phenotype as well as p66Shc expression and...

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Identifiers

PMID: 31323685
DOI: 10.1093/eurheartj/ehz196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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