Pregnancy and lactation interfere with the response of autoimmunity to modulation of gut microbiota

Abstract excerpt

BACKGROUND: Dysbiosis of gut microbiota exists in the pathogenesis of many autoimmune diseases, including systemic lupus erythematosus (lupus). Lupus patients who experienced pregnancy usually had more severe disease flares post-delivery. However, the possible role of gut microbiota in the link between pregnancy and exacerbation of lupus remains to be explored. RESULTS: In the classical lupus mouse model MRL/lpr,...

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