Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Coevolution of the Spexin/Galanin/Kisspeptin Family: Spexin Activates Galanin Receptor Type II and III

11 Feb 2014

Abstract excerpt

The novel neuropeptide spexin (SPX) was discovered using bioinformatics. The function of this peptide is currently under investigation. Here, we identified SPX along with a second SPX gene (SPX2) in vertebrate genomes. Syntenic analysis and relocating SPXs and their neighbor genes on reconstructed vertebrate ancestral chromosomes revealed that SPXs reside in the near vicinity of the kisspeptin (KISS) and galanin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hypothalamic control of reproductive hormones
Share to Neuropeptides and Animal Physiology
Share to Receptor Mechanisms and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24517231
DOI: 10.1210/en.2013-2106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coevolution of the Spexin/Galanin/Kisspeptin Family: Spexin Activates Galanin Receptor Type II and IIIPMID 24517231Read ↗

Evolution of Structural and Functional Diversity of Spexin in Mammalian and Non-mammalian Vertebrate SpeciesSemantic proximity Read ↗

Molecular Coevolution of Neuropeptides Gonadotropin-Releasing Hormone and Kisspeptin with their Cognate G Protein-Coupled ReceptorsSemantic proximity Read ↗

Comparative Evolutionary Histories of Kisspeptins and Kisspeptin Receptors in Vertebrates Reveal Both Parallel and Divergent FeaturesSemantic proximity Read ↗

Molecular evolution of GPCRs: Kisspeptin/kisspeptin receptors.Semantic proximity Read ↗

Molecular Evolution of Multiple Forms of Kisspeptins and GPR54 Receptors in VertebratesSemantic proximity Read ↗

Functional Significance of GnRH and Kisspeptin, and Their Cognate Receptors in Teleost ReproductionSemantic proximity Read ↗

Overview and New Insights Into the Diversity, Evolution, Role, and Regulation of Kisspeptins and Their Receptors in Teleost FishSemantic proximity Read ↗

Multiple Kisspeptin Receptors in Early Osteichthyans Provide New Insights into the Evolution of This Receptor FamilySemantic proximity Read ↗

Expansion of Secretin-Like G Protein-Coupled Receptors and Their Peptide Ligands via Local Duplications Before and After Two Rounds of Whole-Genome DuplicationSemantic proximity Read ↗

Gene structure of the Kiss1 receptor-2 (Kiss1r-2) in the Atlantic halibut: Insights into the evolution and regulation of Kiss1r genesSemantic proximity Read ↗

Receptor deorphanization in starfish reveals the evolution of relaxin signaling as a regulator of reproductionSemantic proximity Read ↗

The evolution of vertebrate somatostatin receptors and their gene regions involves extensive chromosomal rearrangements.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.