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Article

A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice

26 Jun 2019

Abstract excerpt

with the T164S mutant virus resulted in increased viral load in the mosquito midgut and higher sNS1 production compared to wild-type virus infection. Infection of type 1 and 2 interferon receptor-deficient AG129 mice with the T164S mutant virus resulted in severe disease coupled with increased complement activation, tissue inflammation, and more rapid mortality compared to AG129 mice infected with wild-type...

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PMID: 31243154
DOI: 10.1126/scitranslmed.aat7726

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