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Article

KRAS Binders Hidden in Nature

23 Jun 2019

Abstract excerpt

Abstract Natural products have proven to be a rich source of molecular architectures for drugs. Here, an integrated approach to natural product screening is proposed, which uncovered eight new natural product scaffolds for KRAS—the most frequently mutated oncogenic driver in human cancers, which has remained thus far undrugged. The approach combines aspects of virtual screening, fragment‐based screening,...

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Identifiers

PMID: 31231840
DOI: 10.1002/chem.201902810

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