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Insights into the molecular regulatory network of pathomechanisms in osteochondroma

18 Jun 2019

Abstract excerpt

Osteochondroma is a benign autosomal dominant hereditary disease characterized by abnormal proliferation of cartilage in the long bone. It is divided into solitary osteochondroma and hereditary multiple exostoses (HMEs). The exostosin-1 (EXT-1) and exostosin-2 (EXT-2) gene mutations are well-defined molecular mechanisms in the pathogenesis of HME. EXT-1 and EXT-2 encode glycosyltransferases that are necessary for...

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PMID: 31211456
DOI: 10.1002/jcb.29155

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